Comprehension of communicative intentions: The case of figurative language

This study is concerned with children's comprehension of the communicative meaning of conventional figurative communication acts. We assume that com prehending the communicative meaning of both figurative and non-figurative communication acts involves the same cognitive processes. We hypothesize that the complexity of the mental representations involved accounts for the increasing difficulty in comprehending the very same conventional figurative expression, uttered with a sincere, deceitful or ironic intent. A pre-test on 20 children (7 to 7; 6 year-olds) ascertained the conventionality of the 6 figurative expressions used as the experimental material, e.g. To be as mute as a fish . For each figurative expression we created three different communicative contexts, within which that expression acquired either a sincere, deceitful or ironic communicative meaning. In the experiment, we presented 108 children aged 7 to 10; 6 years with brief audio-recorded stories, each involving a figurative expression in a specific communicative context. The children's performance reflects the predicted trend in difficulty for comprehending the use of the very same figurative expression, from the easiest to the most difficult: sincere, deceitful, ironic. Our results are in favor of a unifying framework for explaining the comprehension of figurative and non-figurative communication acts

Adaptive equalization in coherent receivers using a Stokes space update algorithm

A coherent optical receiver including an optical transducer, an adaptive filter, and a processor updates the adaptive filter according to a metric derived in Stokes space. The optical transducer receives an optical signal corresponding to a modulated signal of symbols. The optical transducer also determines a first signal corresponding to a first polarization of the optical signal and a second signal corresponding to a second polarization of the optical signal. The adaptive filter recovers a first equalized signal and a second equalized signal from the first signal and the second signal. The first equalized signal and the second equalized signal form an equalized modulated signal of symbols. The processor calculates a set of Stokes parameters from the equalized modulated signal and updates the adaptive filter based on a metric derived from the set of Stokes parameters

Effect of transport length and genotype on tonic immobility, blood parameters and carcass contamination of free-range reared chickens

The aim of the present study was to investigate the effect of transport on welfare traits, several haematological parameters and carcase hygiene in two different chicken genotypes (fast- and slow-growing strains) reared under free-range conditions. For this aim, two hundred male chicks, 100 from fast-growing (Ross 308, R) and 100 from slow-growing (Naked Neck, NN) strain were farmed. At the end of the rearing period, at 81 days of age, 56 birds/strain were randomly selected for slaughtering and submitted to two different pre-slaughter conditions: no transport (0h) or 4 hours of transport (4h). Tonic immobility (TI), blood parameters and carcase hygiene traits were determined. Strain and transport significantly affected TI of birds. Both experimental factors and their interaction significantly affected plasma creatine kinase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase. Cholesterol and triglycerides were not different between the experimental groups, whereas glucose decreased after 4 hours of transport in both strains. A significant difference between groups for the heterophils/lymphocytes ratio after transport was also observed, with NN being higher than Ross. Concerning the oxidative stress, we observed a higher ROS production in NN chickens. The carcase microbial characteristics showed a higher level of contamination after the transport (total viable counts), but not concerning the Enterobacteriaceae counts

Targeting Taxanes to Castration-Resistant Prostate Cancer Cells by Nanobubbles and Extracorporeal Shock Waves

To target taxanes to castration-resistant prostate cancer cells, glycol-chitosan nanobubbles loaded with paclitaxel and docetaxel were constructed. The loaded nanobubbles were then combined with Extracorporeal Shock Waves, acoustic waves widely used in urology and orthopedics, with no side effects. Nanobubbles, with an average diameter of 353.3 ± 15.5 nm, entered two different castration-resistant prostate cancer cells (PC3 and DU145) as demonstrated by flow cytometry and immunofluorescence. The shock waves applied increased the amount of intracellular nanobubbles. Loading nanobubbles with paclitaxel and docetaxel and combining them with shock waves generated the highest cytotoxic effects, resulting in a paclitaxel GI50 reduction of about 55% and in a docetaxel GI50 reduction of about 45% respectively. Combined treatment also affected cell migration. Paclitaxel-loaded nanobubbles and shock waves reduced cell migration by more than 85% with respect to paclitaxel alone; whereas docetaxel-loaded nanobubbles and shock waves reduced cell migration by more than 82% with respect to docetaxel alone. The present data suggest that nanobubbles can act as a stable taxane reservoir in castration-resistant prostate cancer cells and shock waves can further increase drug release from nanobubbles leading to higher cytotoxic and anti-migration effect

Retroperitoneal liposarcoma associated with small plaque parapsoriasis

<p>Abstract</p> <p>Background</p> <p>Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. Production of Granulocyte-Colony Stimulating Factor, alpha-fetoprotein, paraneoplastic pemphigus and leucocytosis, Acrokeratosis paraneoplastica (Bazex's syndrome) are reported.</p> <p>The present report describes a case of retroperitoneal liposarcoma associated with small plaque parapsoriasis. Our search in the English literature of such a kind of association did not reveal any case reported.</p> <p>Case presentation</p> <p>A 74 year male patient was admitted to our hospital because of the presence of an abdominal mass in right iliac fossa. He also complained of a two-year history of psoriasiform eruptions. The CT scan showed a retroperitoneal pelvic mass. Therefore surgical resection of the tumor was performed. After surgery, the skin eruptions disappeared completely in seven days and so a diagnosis of parapsoriasis syndrome was done.</p> <p>Conclusion</p> <p>Parallel disappearing of skin eruptions after surgery, typical clinical picture and not specific histology of the cutaneous lesions suggest the diagnosis of small plaque parapsoriasis. Therefore we propose to add Small Plaque Parapsoriasis to the list of paraneoplastic syndromes associated to liposarcoma.</p